More than 30 years after it was identified as a key ‘longevity gene,’ the protein klotho has been used to boost the cognitive function of aging rhesus macaques, paving the way for human trials.
  • Klotho protein identified as key ‘longevity gene’
  • Improvement of cognitive functions of aging rhesus monkeys with the introduction of klotho protein
  • Working memory and task performance improved in 18 rhesus monkeys
  • Memory improvement lasts at least two weeks
  • The protein klotho plays a key role in aging by regulating phosphate levels and insulin signaling.
  • Protein is made in the kidneys and depleted with age
  • Klotho protein could be used to extend life and improve cognition in humans