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  • deranger
    2·
    3 months ago

    With alcohol it’s very clear that there’s one organ doing the heavy lifting

    It’s not your liver, it’s your GABA receptors downregulating that gives you a tolerance. Your liver helps with the duration and hangover but the lower peak intoxication is mediated by the receptors. Likewise with cannabis, your THC receptors downregulate to give you a weed tolerance. It is also processed by the liver.