Proxmox is not a complete replacement for VMware. Proxmox still does not have a distributed resource scheduler or distributed power management for it’s cluster which means the only time a VM will move between nodes is if a node goes down.

There’s no official support for VDI within proxmox and all the third party tools are janky at best, definitely not ready for enterprise level deployments.

Nvidia does not officially support vGPUs on proxmox. You can get it working but it’s definitely not something you’d want to run on production.