I personally separate my files into two separate zpools, but they may as well be directories. One zpool contains data that while it would suck to lose, wouldn’t be a disaster. That data is stored on a mirrored disk, but isn’t backed up anywhere else. The other zpool contains data that I absolutely do not want to lose. That is stored on the same mirrored disk setup, but is also backed up to Backblaze every night using Restic. VMs which produce data I don’t want to lose store this data in this directory, so it gets backed up too.