- Machine learning can speed up drug discovery and reduce costs.
- Senolytics are drugs that slow down aging and prevent age-related diseases.
- Aging cells secrete inflammatory proteins that can cause disease.
- Eliminating senescent cells may ease the course of diseases including diabetes, COVID, pulmonary fibrosis and cancer.
- About 80 senolytics are known, but only two have been tested in humans.
- Machine learning models can identify new candidate senolytic drugs.
- The best AI model identified 21 molecules with a high probability of being senolytics.
- Three of these drugs (periplocin, oleandrin, ginkgetin) are able to destroy senescent cells.
- Oleandrin proved to be more effective than the most effective senolytic drug.
- An interdisciplinary approach can accelerate the search for treatments for diseases.
AFAIK, as an example Aloe Vera is supposed to be toxic if ingested straight from plant. But has hydrating and healing properties on skin when burned / sunburned