AI: American researchers have found that when the first and second doses of an mRNA vaccine against the SARS-CoV-2 coronavirus are administered into different arms, the immune response to it is stronger than when a booster is injected into the same arm. This contradicts the findings of another scientific group. The work by Marcel Kerlin and colleagues involved 947 people aged 24–84 years who received at least two doses of the BNT162b2 mRNA vaccine. In all of them, the levels of specific immunoglobulins for the spike protein, receptor binding domain (RBD) and viral nucleocapsid in the blood serum were measured at 0.6; 8 and 14 months after the booster dose. In those who received the vaccine in different arms, titers of binding and neutralizing antibodies were higher and progressively increased over time. Larger clinical and immunological studies are needed to resolve this controversy.
AI: American researchers have found that when the first and second doses of an mRNA vaccine against the SARS-CoV-2 coronavirus are administered into different arms, the immune response to it is stronger than when a booster is injected into the same arm. This contradicts the findings of another scientific group. The work by Marcel Kerlin and colleagues involved 947 people aged 24–84 years who received at least two doses of the BNT162b2 mRNA vaccine. In all of them, the levels of specific immunoglobulins for the spike protein, receptor binding domain (RBD) and viral nucleocapsid in the blood serum were measured at 0.6; 8 and 14 months after the booster dose. In those who received the vaccine in different arms, titers of binding and neutralizing antibodies were higher and progressively increased over time. Larger clinical and immunological studies are needed to resolve this controversy.