Could the sweetened drinks we're consuming be making us feel a little more anxious? A 2022 study looking at the effects of the artificial sweetener aspartame on mice suggests that it's a possibility that's worth investigating further.
The FDA recommended maximum DIV for aspartame for humans is 50 mg/kg (33). Based on allometric conversion utilizing pharmacokinetic and body surface area parameters (43), the mouse equivalent of the human DIV is 615 mg/kg/d. Therefore, the male mice received a daily aspartame dose equivalent to 14.0%, 7.0%, and 3.5% of the FDA recommended human DIV, and the females received a dose equivalent to 15.5%, 7.7%, and 3.9% of the human DIV.
It’s a lot to unpack, but my interpretation is that it’s been adjusted for a rat
Here’s the relevant sentence in the study:
It’s a lot to unpack, but my interpretation is that it’s been adjusted for a rat