That’s long been my approach with the starting meds reversed (ibuprofen, then Tylenol if needed). Acetaminophen/paracetamol’s therapeutic dosage is much closer to the amount required for liver toxicity than Ibuprofen’s is for kidneys, so I think it’s better to start with the lower-risk medication. If I’m in the middle of a multi-day episode that’s well-managed with just one medication at the regular dosing schedule, I will often alternate between them.
That’s long been my approach with the starting meds reversed (ibuprofen, then Tylenol if needed). Acetaminophen/paracetamol’s therapeutic dosage is much closer to the amount required for liver toxicity than Ibuprofen’s is for kidneys, so I think it’s better to start with the lower-risk medication. If I’m in the middle of a multi-day episode that’s well-managed with just one medication at the regular dosing schedule, I will often alternate between them.