A level 12-20 D&D adventure would pose major new design challenges.
5e wasn’t tested past level 10. It’s incredibly unbalanced. But I’m confident Larian could figure out a way for it to feel good.
Even a D&D campaign at this level is hard to DM, I cant imagine the complexity in trying to really gameify this when especially at the end your players are gods.
Cast wish, may as well just let players write their own code for what they want.
Sure bigger stronger enemies are available but parties become so powerful i can’t see it being easy.
I would say just leave those aspects out of the game, or put strict limitations on their usage. You could isolate higher magic abilities to specific items (e.g. deck of many things).
It is complex, however I think if you look to games like Neverwinter as a template for moving forward (absent microtransactions).
I’d actually rather love some sort of different campaign or some adventure packs, similar to how D&D does it with their expansion books.
Either that or a great mod tool that would allow for something like that. Doesn’t even need support for added races, classes or traits. Just a map editor with a mob editor slapped on top would be a gamechanger