Hi everyone! I was diagnosed a few years ago in my early 30s, and started taking Adderall along with some different drugs for anxiety as well.
With Adderall and then Wellbutrin, even in small dosages, I notice that my HRV Stress (recorded on a Garmin 945 Forerunner) is significantly elevated for the entire day. When I used to take a midday and evening dose of (instant release) Adderall, it severely impacted my sleep. I also tried extended release taken in the morning, and that caused sleeping issues as well. So did an extended release of Wellbutrin.
Basically, any benefits those medications provide (and it didn’t really feel like it was helping) were offset by the bodily impact.
Has anyone had a similar experience with either of these medications? Any notable co-morbidities or changed metabolism or something that you identified as causing these symptoms? Did Ritalin or Strattera work for you when Adderall did not? I’ve been cycling through other non-stim medications with my provider, but haven’t found anything that provides benefits for ADHD (I’m currently on guanfacine and zoloft, which mitigates my anxiety at least).
Mydayis (dextro- and amphetamine salts) seems to be more stressful on me than Vyvanse. The extended release mechanism also varies things. But hey, there’s a new goddamn shortage every week and we go with what works well enough.
As it was explained to me, you basically got three options: amphetamines, methylphenidates, and the “other stuff” (Wellbutrin, strattera, qelbree, guanfacine etc). This is a purely anecdotal analogy and oversimplification of how stuff works as it was told to me:
Amphetamines (adderall etc) hit the front door in the front of the brain — more dopamine, intense concentrated focus. Methylphenidates (Concerta etc) hit the back door in the front of the brain — more norepinephrine, longer-lasting, more alertness. The Other Stuff is back of brain, like if you turned down the ambient noise of a room.
Long and short of it is that one of these three approaches will tend to work well for an individual with ADHD, but the other two not so much. It’s pure trial and error, and it sucks, but with a decent provider and time (and insurance) you can eventually settle on one at a particular dose. Best of luck!
This has been my experience as well.