I’ll go first. Mine is the instant knockout drug. Like Dexter’s intramuscular injection that causes someone to immediately lose consciousness. Or in the movie Split where there’s the aerosol spray in your face that makes you instantly unconscious. Or pretty much any time someone uses chloroform.
Picking a lock with just one pick. That’s not how it works, you need one to apply a rotating force and another one to lift the individual pins. Sometimes shows even get it right in one season and then totally blow it in the next one.