There’s a couple of quests that have a time limit, and it’s easy to not be aware since all the others can be completed whenever. I only knew beforehand because I read about it, and I’m glad I did, because letting them unintentionally expire has really bad outcomes.

Also I got a mod for infinite respecs. Otherwise I would worry about wasting finite consumable points and never spend them.

Especially Phantom Liberty. I went in blind, made decisions, lived to regret them, fucked up everything, and loved every minute of it.