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Poppers can also be used in a recreational setting, it gives a head rush and is hilarant, but tends to give me headaches after too many uses. It’s sold legally at some festivals around me.
For MDMA I still think it’s as safe as LSD, and I’d rate it safer than alcohol. You need to respect a few rules, especially like you said with serotonin (SSRIs are a no go), and to manage your body during the high, same as other long acting drugs. But the risks of not getting the correct product is more a problem of the drug war than of the drug itself. Thankfully I’m somewhere where MDMA is cheap, and there is little to no reason to f you over with fake or other drugs like speed which cost more. Testing your product is also best.
As for the exhaustion and come down go, I found that most ppl tend to take way too much, my rule goes body weight(kg) in mg max per dose, and 2-3 doses depending on the party length, I rarely need more to have a good time, and rarely have a harsh comedown. Also pills nowadays tend to become way too potent, with some having 350+mg per, which is way too much in one night, and inconceivable swallowing it whole.
I won’t judge the op on the fully developed brain part, I started testing all that stuff at 18, and I don’t think it had such a negative impact on me (but who knows). But I did realize quickly the impact it had at that time and scaled back massively afterwards.
I think also one of the issues with some of the drugs being “safe” is that it signals them being benign, but they still are hard drugs and they should be treated with care. Maybe op’s friends see his confidence and mistake that as carelessness instead of confidence in his research and experiences.
I mean for privacy things it makes sense to avoid leaking anything. But I fail to understand where the danger is to have anonymous data that says a user installed “Ubuntu-24.04-wappity-whatever.iso” to “KINGSTON DATA TRAVELER 32GB” at some point.