AFAIK it all boils down to the fact that during embryonal development our cells, which at that point were just a blob of undifferentiated autonomous chemical machines, somehow managed to unanimously agree upon the cardinal directions (up-down, left-right, front-back) for future development - and thanks to this, we don’t have toes growing out of our ears.
Imagine if you suddenly sprouted a tumor with functional tastebuds in your colon
“So what brings you into the doctors office today?”
“Well for some reason everything I eat ends up tasting like shit.”
Ugh and I thought burping after having Fish Oil pills was bad…