I found that things became much more pleasant on here when I blocked hexbear. I recently blocked lemmy.ml as well, but I may reverse that if I find that I’m missing too much good content.
I’m open to other ideas on how to mostly avoid people who love conflict or argue in bad faith.
I haven’t blocked an entire instance but I do have a list of communities I’ve blocked.
Other than that, I just block the user, not the instance.