• HonoraryMancunian@lemmy.world
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    1 year ago

    Matt Le Blanc:

    "…I guess you’re keeping the 20 bucks you owe me.”

    This is exactly the kind of humour Perry would’ve appreciated

    • NoSpiritAnimal@lemmy.world
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      1 year ago

      He is not just truckin’ along. The man looks like someone’s aunt is trying to build mass. He looks like an uncooked weisswurst got a planet fitness membership. He is a torso made manifest. Hair plugs and ozempic riding the right-wing-pipeline down a k-hole.

    • sharpiemarker@feddit.de
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      1 year ago

      Hot tubs + drugs don’t mix. Even alcohol is dangerous because the effect of the hot tub increases the effects. We bought a hot tub recently and they’re are dozens of warnings about drugs/alcohol.

      My recommendation to Elon would be to have a nice big dose and take a long dip.

    • RocketBoots@programming.dev
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      1 year ago

      Calling them horse tranquilizers is misleading. Ketamine was and still is used in medicine and is on the WHO list of essential medicines.

      My cat is prescribed gabapentin. Some even get tramadol. Warfarin literally was rat poison until we got all but the craziest SOBs with an abundance of vitamin K in they’re veins.

      • Dozzi92@lemmy.world
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        1 year ago

        Yeah, I feel like there is a war on K because it can absolutely replace opiates in pre-hospital pain management. Break a leg? Let the medics hit you with ketamine. Oh, your BP is a little low? No worries, ketamine doesn’t care.

        It is better than an opiate with none of the contraindications. And I’m oversimplifying, but I can’t help but think some of this news coming out is almost a hit piece to dub ketamine dangerous, when it is, in fact, magnitudes safer than opiates.

      • Hadriscus@lemm.ee
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        1 year ago

        oh, I tried that last month ! Pretty sweet high, relaxing. Like a really soft mdma (really soft!)

        (I was talking about gabapentin, just realized it was ambiguous)

  • Rob T Firefly@lemmy.world
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    1 year ago

    When Friends was current I wasn’t a fan, the small bits I’d seen mostly annoyed me and - disaffected gothy teens/early twenties guy that I was - I dismissed it as one of those things everyone in the mainstream liked and was therefore obviously garbage.

    Nowadays I’m married to a Friends fan who has begun showing me the series. As we progress through the box set I’m realizing it’s actually pretty good, a couple of the characters actually still annoy me when they’re focused on but there’s a ton else going on that’s pretty entertaining. I’m particularly surprised to be enjoying Chandler so much.

    It’s very sad what Matthew Perry went through in life and how he died, but I’m now belatedly appreciating some of the work he did.

      • kameecoding@lemmy.world
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        1 year ago

        you can’t just do that mate, same with Seinfeld, they were filmed in front of a live audience, they had to stop for laughter otherwise you wouldn’t hear what they are saying.

        or are you gonna come out and say Seinfeld isn’t hilarious?

    • Underwaterbob@lemm.ee
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      1 year ago

      I’m still not sure I’d call it good, but it was a big step up from sitcoms before it. It tried pretty hard to not be sexist, and introduced some diversity that wasn’t just John Ritter pretending to be gay for lulz. It is still spectacularly unrealistic, but whatever. It’s a sitcom! It does have some genuinely funny moments.

      I still periodically get “Smelly Cat” stuck in my head. Fuck, I’m guilty of making Ross-esque synthesizer music…

      • Rob T Firefly@lemmy.world
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        1 year ago

        Very true. There are also definitely still some 1990s-era LGBTQIA+ phobic jokes which were wrong then and really stick out now, but in general I’d call the writing surprisingly decent.

        As a New Yorker, though, I still couldn’t afford that apartment in a million years.

        • Tavarin@lemmy.ca
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          1 year ago

          I still couldn’t afford that apartment in a million years.

          Neither could they, it was rent controlled due to Monica’s grandmother living there, and they illegally kept her name on the lease for the cheap rent.

          And Chandler made good money, so he could afford the smaller 2 bedroom.

  • saze@feddit.uk
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    1 year ago

    Damn, I did not know Ket could depress respiration like this! In fact Ket is used medicinally in place of opioids as it doesn’t depress respiration. But here is the TIL part: it should not be mixed with benzos or alcohol (or other depressants I would imagine). I don’t use bu I hope someone who does get to read this.

    • 14th_cylon@lemm.ee
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      1 year ago

      ketamine is anaesthetic and was used in the past in combat medicine and such, because it is quite safe when administered by untrained staff. the fact it is used to treat depression is new to me, but getting in the pool while high on it is the most stupid idea ever :(.

    • prole
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      1 year ago

      He was in the bathtub and drowned. If you take enough ketamine, it will literally incapacitate you (for many, that’s the entire point). He did this in a bathtub.

      He did not die from overdosing on ketamine, because that’s nearly impossible. He was stupid and incapacitated himself in a bathtub and drowned. It sucks, and it’s easy to just blame a chemical.

      I’m sure there are people who die after having a couple drinks and getting into the tub, but do we then say that they “died due to the acute effects of alcohol”? No. We say they drowned.

  • lingh0e
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    1 year ago

    Ketamine’s effects on respiratory shit is serious.

    I almost stopped breathing during an assisted experience because I didn’t realize mixing K with benzos was dangerous.

    • intensely_human@lemm.ee
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      1 year ago

      It’s how Elijah McClain died too. Young kid stopped by police for matching the description. They shot him full of ketamine and he died of respiratory failure.

      • takingbacksunday@lemmy.world
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        1 year ago

        Can’t recall all the details, but the impression I got was his respiratory failure was caused by the officer choking him with a knee on his windpipe. EMTs did give a very high dose of ketamine at 5mg/kg body weight, whereas I usually use 0.5-1mg/kg body weight to put patients under surgical anesthesia.

    • sock@lemmy.world
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      1 year ago

      was it Ks resp effects or the combination with another downer that was serious

      and therefore not Ks fault and solely youre fault for not researching the chem

  • IDontHavePantsOn@lemm.ee
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    1 year ago

    Im fairly certain that what I’m about to say will be disliked by ketamine users and abstainers.

    Ketamine is garbage at everything besides temporarily lobotomizing people. It works for it’s many uses because it makes the user stupid. It’s often given to suicidal people, not because it’s a miracle drug, but because it incapacitates them in a safe manner.

    That said, it’s great at making people too stupid to be able to hurt themselves, most of the time. It’s great at numbing psychological pain because the user will be too stupid to conceptualize their own thoughts or realize where they are physically.

    It’s also hard on the urinary system and has a fleeting high.

    If you like ketamine then by all means, you do you. If you may be interested in trying ketamine, become a zombie safely, just don’t expect it to cure your depression, woes, or any of your other problems.

    • StorminNorman@lemmy.world
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      1 year ago

      Yeah, I’m gonna take the peer reviewed studies results that show that ketamine is quite effective with relieving drug resistant depression over this post of yours…

      • figaro@lemdro.id
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        1 year ago

        It is useful in creating a sense of disassociation of self - the same thing that meditation does. It even affects the same regions of the brain as meditation. When used carefully, with therapeutic intent, it can be an effective treatment for depression.

        Recreational use is sketchy, definitely. But the science is there for using it therapeutically.

      • dangblingus@lemmy.dbzer0.com
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        1 year ago

        But your assessment of its efficacy is not contradictory to DontHavePants observation. They didn’t say it wasn’t effective.

      • madcaesar@lemmy.world
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        1 year ago

        I have no dog in this fight, but any studies done on brain chemistry and psychological effects need to be taken with a grain of salt. We know so little about the brain and consciousness that most of the stuff we’re trying and doing are educated guesses.

        • StorminNorman@lemmy.world
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          1 year ago

          Ketamine is garbage at everything besides temporarily lobotomizing people. It works for it’s many uses because it makes the user stupid. It’s often given to suicidal people, not because it’s a miracle drug, but because it incapacitates them in a safe manner.

          This quote from you contradicts what you’ve just said.

          • IDontHavePantsOn@lemm.ee
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            1 year ago

            It doesn’t. I can speak to it’s mode of action without speaking to it’s reason of use or efficacy. It’s highly effective. It’s great at what it’s used for. It also temporarily makes the user stupid and incapacitates them.

            • Metacortechs@lemmy.world
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              1 year ago

              That isn’t it’s mode of action, at all.

              It also doesn’t make you stupid, it is a disassociative anesthetic so you lose touch, to varying degrees, of your senses. At high enough doses even your sense of hearing becomes strange and I would bet if my doc gave me more it would fail almost completely. That’s not a place I want to go however.

              Despite that, and appearing to be incapable of coordinated movement or speech, the mind is still active. Altered, yes. But active and intact. I am always aware of my partner in the room/bed with me, the dog checking things out, I just choose not to interact with them to continue exploring memories, or alien landscapes, or just turn off my mind, listen to the music, and let the drug work while the most fantastic and surreal images come and go.

              I’m here today because of ketamine. Disinformation and pearl clutching threatens to reduce access to it, and could cost lives, speaking only of this one niche use.

              • IDontHavePantsOn@lemm.ee
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                1 year ago

                I’m not trying to diminish anyone’s experiences with ketamine, or reduce anyone’s access to it, though I do think it’s funny everyone thinks that some asshole on the internet has that ability.

                Are you able to stand up when using ketamine? How about run? Could you tell me your personal details such as name/date/address? Could you tell me the time? Could you remember your mother’s phone number? Could you take a bath? Could you safely use a knife? Could you melt into nothingness and lose all sense of self, physicality and emotion?..wait strike that last one. Of course you could.

                Now we’re at the point that we all realize dissociation is to become stupid and incapacitated. Anesthitized even?

                • StorminNorman@lemmy.world
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                  1 year ago

                  Ahhhhh, so you did come back to say more dumb stuff. I literally baby sat a group of friends on the stuff two weekends ago. Sure, they said some amusing things, but at least 95% of what they said was perfectly coherent and made sense. As evidenced by one of them saying “you know you’re getting old when you have more cos you’re lower back starts to ache”. By your description, that should not have been possible. Yet it was. Sure, you enter a k-hole and you’re good for nothing, but most K experiences don’t enter that and people can function fine enough on it - like most drugs the intensity of effect is dose dependent. But like I said in a previous comment, you seem to be stuck in the 1950s and their anti drugs hysteria.

              • IDontHavePantsOn@lemm.ee
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                1 year ago

                I’ve ingested a ton of ketamine myself, so theres no pearl clutching here. I’ll be back tomorrow to continue arguing semantics.

                • prole
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                  1 year ago

                  So you sound like someone with some experience using drugs (particularly those of psychedelic or hallucinatory nature), right?

                  So you would know that drugs effect everyone differently. Personally, I never abused ketamine, but I have k-holed a handful of times, and my personal experience was that it had a profound effect on me in many ways.

                  But that’s just my personal experience. Nothing more, nothing less.

                  Anyway, those who know, know MXE (methoxetamine) was way better for that brief period of time before the supply permanently dried up.

            • StorminNorman@lemmy.world
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              1 year ago

              You didn’t though. You used a blanket statement. As evidenced by your use of the word “everything”. Your entire initial comment reads as if it was written in the grip of anti drugs hysteria in the 1950s and shows none of the nuance you’re now trying to claim it does.

              You’re also wrong on its mode of action, so you’re not even speaking to that. It doesn’t work by making the user “too stupid to conceptualize their own thoughts or realize where they are physically”.

              • chitak166@lemmy.world
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                1 year ago

                He said everything except “temporarily lobotomizing people” which was clearly hyperbole.

                He then gave examples where the sedation provided by ketamine can be beneficial.

    • prole
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      1 year ago

      Or, get this, everyone experiences drugs differently and your bad anecdote is irrelevant next to the mountains of evidence and peer reviewed studies.

    • butterflyattack@lemmy.world
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      1 year ago

      I would add to this that anyone doing ketamine should not do it in the bath, which seems to be what happened here. The same happened to someone I knew, she drowned in the tub.

      • driving_crooner@lemmy.eco.br
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        1 year ago

        Any drug close water where you can drown is a recipe for disaster. Someone I knew pop an acid tab at the beach and drown itself.

      • prole
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        Yeah, “don’t k-hole in the bathtub” seems like pretty good (and hopefully obvious) advice. This seems more like user error than the acute effects of the drug itself.

        He didn’t die from overdosing on ketamine, because that’s nearly impossible.

        He drowned.

    • ImFresh3x
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      1 year ago

      I judge my desire to try drugs by how people act when they’re on them. Do they look like they’re having fun at least? Two drugs I’ve never had an interest in:

      Ketamine

      Nitrous

      • prole
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        1 year ago

        That’s unfortunate. The effects of many drugs can be entirely mental rather than visual, leaving the person looking like they’re just laying down with their eyes closed, or staring into space.

        Particularly, ketamine, as a dissociative, at higher doses, is entirely in your mind. What a person in that state looks like from the outside is zero indication of what they are experiencing.

        • ImFresh3x
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          1 year ago

          It’s not unfortunate. To me drugs are entirely unnecessary to begin with. And if I choose to use them it’s to enhance an activity, not to replace an activity or be an activity on its own. I’ll be fine.

          • prole
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            1 year ago

            Well that’s not what we were talking about though, was it? We were talking about you judging people based on how they may look while under the influence. That’s ignorant.

            Also, I find this to be amusing:

            To me drugs are entirely unnecessary

            Uh huh, so I guess antibiotics are off the table? I sure hope you don’t die from a minor infection. Hope you never get diabetes or high blood pressure. No cough medicine or allergy medicine either, that’s annoying. I hope you don’t have any serious allergies, because EpiPens sure as shit count as “drugs”.

      • Dozzi92@lemmy.world
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        1 year ago

        To each their own for sure, but that right there is a combination for some very strange times. Sometimes fun is becoming part of the couch and traveling into outer space. They’re definitely not all get up and dance and have fun, though.

    • You999
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      1 year ago

      To expand on the urinary issues ketamine causes, the problem is that ketamine will recrystallize inside your blatter and ketamine crystals can be pretty sharp.

    • chitak166@lemmy.world
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      1 year ago

      Ketamine is definitely up there with ‘hip’ drugs not worth trying.

      Along with MDMA and Xanax.

      I don’t really respect anyone who does these because they’re usually living a lifestyle that leads to nowhere.

      • smooth_tea@lemmy.world
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        1 year ago

        MDMA not worth it? It’s euphoria and love in a pill, not addictive, and quite safe when you do not abuse it. Millions of people use it and have been using it for about half a century and the vast majority of it restricts it to when they’re partying with few side effects. I think you misjudge its use a bit.

        Yes it can be acutely abused because you’re chasing the dragon on nights that you do use it, but that is also a result of its illegal nature and a lack of education.

        Of the chemical variants of drugs, I’d say it’s probably one of the few that is actually worth it, besides LSD.

        • Dozzi92@lemmy.world
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          Yeah, I try to tell people that there’s value in MDMA beyond just a night out dancing. My favorite times have been on a couch with friends, getting deep into one another and kind of exploring your minds. I’ve had some incredibly important and memorable conversations with people that I was able to become very close with because MDMA let us drop the walls and talk about things, which is something I cannot do face to face with someone sober. And I’m not an introvert by any stretch, I have no problem being the center of a conversation, I have no problem listening to others, but opening up about personal issues was something MDMA let me do, and say things I never could put into words.

          I’ve also stood in front of a wall of speakers and had bright lights and bass music thrown at me, and that’s also fun.

      • prole
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        1 year ago

        You’d be shocked by how many very successful and incredibly intelligent people have used drugs (including MDMA). Many still use them regularly. MDMA, in the right setting and in moderation, can (will) be a life-affirming and beautiful experience.

        This honestly sounds like something a child would say after having D.A.R.E. in elementary school.

          • pineapple_pizza@lemmy.dexlit.xyz
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            1 year ago

            I know people like this. Though I should probably define regularly as once every few weeks for k. Probably closer to like 2 to 4 times a year for MDMA. Obviously if you’re doing stuff every day then you won’t be productive in a job

          • prole
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            1 year ago

            You literally just replied to one, my guy.

            And yes, I know plenty of people like that. And chances are, so do you. You just don’t know it.

            Edit; in case you’re young, I don’t want anyone to take this as evidence that “drugs are ok”, or “they lied to us about cannabis/MDMA, so that means they lied about heroin too.” No. This is why we’d be much better off if they were just honest from the beginning. Not all drugs are created equal, but also the classification system in the US (and most modern nations) is not necessarily based on potential harm.

            So to be clear, my comment is not necessarily true for all drugs, I am specifically referring to MDMA right now (which, before becoming illegal, was used by doctors to great effect as an aid in couples’ therapy).

      • Hadriscus@lemm.ee
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        Hmmm, I don’t know the second one but mdma is great fun. Of course you have to be in a good state of mind before trying, but it’s a potent empathogen that has its uses.

        • EatATaco@lemm.ee
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          One of the most fun nights of my life is when I went to visit a friend at his university, we took some and he immediately ended up with some girl and disappeared on me.

          So I decided that I would just wander his campus looking for parties. I took shots with frat boys, danced with some gays guy out dressed in drag, played chess with some guy on the quad (he would have destroyed me even if I was sober), found another friend and went and partied with her and her lesbian friends (“wait you’re a lesbian now?” “Maybe not sure”) and then made the biggest mistake of my life when I turned down joining them when I was making a hasty exit after I noticed one of the girls was eating the other out right next to me on the couch.

          • Hadriscus@lemm.ee
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            wild 😁 Yea I get how you’d want a do over heheh

            My experience is very vanilla coming after yours, but we had some of that and spent the entire night in my last floor apartment just chatting and drinking looking at the sea. It was full moon too. At one point I must have thought it was around midnight, I peeked at the east-facing window in my room and a big ball of fire was burning on the horizon. Time really flew this night…

    • kernelle@0d.gs
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      Perry had been undergoing ketamine infusion therapy prior to his death, reportedly for depression and anxiety. The toxicology report adds: “At the high levels of ketamine found in his postmortem blood specimens, the main lethal effects would be from both cardiovascular overstimulation and respiratory depression.”

      He was getting it as treatment, but technically yes

      • Thetimefarm@lemm.ee
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        He was definately taking it recreationally too, a therapeudic dose wouldn’t even be close to enough to OD on. Long term ketamine use can have it’s own risks if the dose isn’t kept very low.

  • dangblingus@lemmy.dbzer0.com
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    1 year ago

    Cue all of the commenters saying how amazing unprescribed unmonitored narcotic abuse is great for their mental health.

  • computerscientistI@lemm.ee
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    1 year ago

    I had no idea about what ketamine actually is, It seemms most likely to me that it was administered via IV by a MD, no? Wasn’t this manslaughter by the doctor, then?

    • Agent641@lemmy.world
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      1 year ago

      Ketamine can be taken as pills, liquid ingested, snorted, injected (self administered), or up the bum.

      You dont have to do all these at the same time unless youre trying to be the heavyweight world champion of K-holeing